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AR453588(CAT: I017350) is a potent and orally bioavailable glucokinase activator (GKA) with an EC50 of 42 nM, demonstrating strong potential in anti-diabetic research. By enhancing glucokinase activity, AR453588 promotes glucose utilization and exhibits significant anti-hyperglycemic
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Haendler Natermann Sport GmbH ar transcript variant 2
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R&D Systems antibodies probing ar45
Chronic intermittent hypoxia (CIH) does not impact androgen receptor <t>AR45</t> protein expression in male or female rats. AR45 protein expression was quantified as a percentage of Beta actin expression (% β-actin) in dorsal hippocampus [CA1 (A) , CA3 (B) , dentate gyrus (DG, C )], entorhinal cortex (ETC, D ), thalamus (TH, E ), and striatum (STR, F ) brain regions from young adult male and female Sprague-Dawley rats exposed to normoxia (gray bar, white circles) or CIH (red bar and circles) for 14 days. Data were analyzed by Two-Way ANOVA (sex, CIH) with Tukey’s multiple comparisons tests; n =4–6/group.
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Chronic intermittent hypoxia (CIH) does not impact androgen receptor <t>AR45</t> protein expression in male or female rats. AR45 protein expression was quantified as a percentage of Beta actin expression (% β-actin) in dorsal hippocampus [CA1 (A) , CA3 (B) , dentate gyrus (DG, C )], entorhinal cortex (ETC, D ), thalamus (TH, E ), and striatum (STR, F ) brain regions from young adult male and female Sprague-Dawley rats exposed to normoxia (gray bar, white circles) or CIH (red bar and circles) for 14 days. Data were analyzed by Two-Way ANOVA (sex, CIH) with Tukey’s multiple comparisons tests; n =4–6/group.
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Sinopharm ltd hydroiodic acid ar 45 wt.% in water
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HiMedia Laboratories 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide mtt (ar)
Chronic intermittent hypoxia (CIH) does not impact androgen receptor <t>AR45</t> protein expression in male or female rats. AR45 protein expression was quantified as a percentage of Beta actin expression (% β-actin) in dorsal hippocampus [CA1 (A) , CA3 (B) , dentate gyrus (DG, C )], entorhinal cortex (ETC, D ), thalamus (TH, E ), and striatum (STR, F ) brain regions from young adult male and female Sprague-Dawley rats exposed to normoxia (gray bar, white circles) or CIH (red bar and circles) for 14 days. Data were analyzed by Two-Way ANOVA (sex, CIH) with Tukey’s multiple comparisons tests; n =4–6/group.
3 (4,5 Dimethylthiazol 2 Yl) 2,5diphenyltetrazolium Bromide Mtt (Ar), supplied by HiMedia Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ATCC ar42 jq652592 ar45 ar45 jq652593 ar46 ar45 jq652593 ar46 jq652594 ar47
Chronic intermittent hypoxia (CIH) does not impact androgen receptor <t>AR45</t> protein expression in male or female rats. AR45 protein expression was quantified as a percentage of Beta actin expression (% β-actin) in dorsal hippocampus [CA1 (A) , CA3 (B) , dentate gyrus (DG, C )], entorhinal cortex (ETC, D ), thalamus (TH, E ), and striatum (STR, F ) brain regions from young adult male and female Sprague-Dawley rats exposed to normoxia (gray bar, white circles) or CIH (red bar and circles) for 14 days. Data were analyzed by Two-Way ANOVA (sex, CIH) with Tukey’s multiple comparisons tests; n =4–6/group.
Ar42 Jq652592 Ar45 Ar45 Jq652593 Ar46 Ar45 Jq652593 Ar46 Jq652594 Ar47, supplied by ATCC, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Sinopharm ltd hydroiodic acid
Chronic intermittent hypoxia (CIH) does not impact androgen receptor <t>AR45</t> protein expression in male or female rats. AR45 protein expression was quantified as a percentage of Beta actin expression (% β-actin) in dorsal hippocampus [CA1 (A) , CA3 (B) , dentate gyrus (DG, C )], entorhinal cortex (ETC, D ), thalamus (TH, E ), and striatum (STR, F ) brain regions from young adult male and female Sprague-Dawley rats exposed to normoxia (gray bar, white circles) or CIH (red bar and circles) for 14 days. Data were analyzed by Two-Way ANOVA (sex, CIH) with Tukey’s multiple comparisons tests; n =4–6/group.
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Chronic intermittent hypoxia (CIH) does not impact androgen receptor AR45 protein expression in male or female rats. AR45 protein expression was quantified as a percentage of Beta actin expression (% β-actin) in dorsal hippocampus [CA1 (A) , CA3 (B) , dentate gyrus (DG, C )], entorhinal cortex (ETC, D ), thalamus (TH, E ), and striatum (STR, F ) brain regions from young adult male and female Sprague-Dawley rats exposed to normoxia (gray bar, white circles) or CIH (red bar and circles) for 14 days. Data were analyzed by Two-Way ANOVA (sex, CIH) with Tukey’s multiple comparisons tests; n =4–6/group.

Journal: Frontiers in Endocrinology

Article Title: Impact of sex and hypoxia on brain region-specific expression of membrane androgen receptor AR45 in rats

doi: 10.3389/fendo.2024.1420144

Figure Lengend Snippet: Chronic intermittent hypoxia (CIH) does not impact androgen receptor AR45 protein expression in male or female rats. AR45 protein expression was quantified as a percentage of Beta actin expression (% β-actin) in dorsal hippocampus [CA1 (A) , CA3 (B) , dentate gyrus (DG, C )], entorhinal cortex (ETC, D ), thalamus (TH, E ), and striatum (STR, F ) brain regions from young adult male and female Sprague-Dawley rats exposed to normoxia (gray bar, white circles) or CIH (red bar and circles) for 14 days. Data were analyzed by Two-Way ANOVA (sex, CIH) with Tukey’s multiple comparisons tests; n =4–6/group.

Article Snippet: Membranes were incubated overnight at 4°C with primary antibodies probing AR45 (1:1000; R&D Systems, Cat. No. MAB5876) or G αq (1:250; Santa Cruz, Cat. No. sc-518023) diluted in 1% non-fat milk/TBST solutions.

Techniques: Expressing

AR45 protein expression is enriched in hippocampal subregions, especially in female rats. AR45 protein expression was quantified as a percentage of Beta actin expression (% β-actin) in dorsal hippocampus [CA1, CA3, dentate gyrus (DG)], entorhinal cortex (ETC), thalamus (TH), and striatum (STR) brain regions from young adult male (gray bar, white circles) and female (red bar and circles) Sprague-Dawley rats. Data were analyzed by Two-Way ANOVA (sex, brain region) with Tukey’s multiple comparisons tests; n =7–12/group. * p < 0.05 vs. female STR; # p < 0.05 vs. male DG.

Journal: Frontiers in Endocrinology

Article Title: Impact of sex and hypoxia on brain region-specific expression of membrane androgen receptor AR45 in rats

doi: 10.3389/fendo.2024.1420144

Figure Lengend Snippet: AR45 protein expression is enriched in hippocampal subregions, especially in female rats. AR45 protein expression was quantified as a percentage of Beta actin expression (% β-actin) in dorsal hippocampus [CA1, CA3, dentate gyrus (DG)], entorhinal cortex (ETC), thalamus (TH), and striatum (STR) brain regions from young adult male (gray bar, white circles) and female (red bar and circles) Sprague-Dawley rats. Data were analyzed by Two-Way ANOVA (sex, brain region) with Tukey’s multiple comparisons tests; n =7–12/group. * p < 0.05 vs. female STR; # p < 0.05 vs. male DG.

Article Snippet: Membranes were incubated overnight at 4°C with primary antibodies probing AR45 (1:1000; R&D Systems, Cat. No. MAB5876) or G αq (1:250; Santa Cruz, Cat. No. sc-518023) diluted in 1% non-fat milk/TBST solutions.

Techniques: Expressing

Androgen receptor AR45 and G αq protein expression are correlated across brain regions in a sex-dependent manner. Scatterplots representing correlations of AR45 and G αq protein expression (quantified as a percentage of Beta actin expression) in dorsal hippocampus [CA1 (A) , CA3 (B) , dentate gyrus (DG, C )], entorhinal cortex (ETC, D ), thalamus (TH, E ), and striatum (STR, F ) brain regions from young adult male (white circles) and female (red circles) Sprague-Dawley rats. Data were analyzed by Spearman correlation with respective r and p -values listed. Dashed trend lines represent the linear relationships within the data determined by linear regression analysis. Dotted lines and shaded regions represent the 95% confidence intervals. n = 16–24/correlation plot.

Journal: Frontiers in Endocrinology

Article Title: Impact of sex and hypoxia on brain region-specific expression of membrane androgen receptor AR45 in rats

doi: 10.3389/fendo.2024.1420144

Figure Lengend Snippet: Androgen receptor AR45 and G αq protein expression are correlated across brain regions in a sex-dependent manner. Scatterplots representing correlations of AR45 and G αq protein expression (quantified as a percentage of Beta actin expression) in dorsal hippocampus [CA1 (A) , CA3 (B) , dentate gyrus (DG, C )], entorhinal cortex (ETC, D ), thalamus (TH, E ), and striatum (STR, F ) brain regions from young adult male (white circles) and female (red circles) Sprague-Dawley rats. Data were analyzed by Spearman correlation with respective r and p -values listed. Dashed trend lines represent the linear relationships within the data determined by linear regression analysis. Dotted lines and shaded regions represent the 95% confidence intervals. n = 16–24/correlation plot.

Article Snippet: Membranes were incubated overnight at 4°C with primary antibodies probing AR45 (1:1000; R&D Systems, Cat. No. MAB5876) or G αq (1:250; Santa Cruz, Cat. No. sc-518023) diluted in 1% non-fat milk/TBST solutions.

Techniques: Expressing

Correlations of plasma testosterone levels and brain androgen receptor  AR45  protein expression across brain regions.

Journal: Frontiers in Endocrinology

Article Title: Impact of sex and hypoxia on brain region-specific expression of membrane androgen receptor AR45 in rats

doi: 10.3389/fendo.2024.1420144

Figure Lengend Snippet: Correlations of plasma testosterone levels and brain androgen receptor AR45 protein expression across brain regions.

Article Snippet: Membranes were incubated overnight at 4°C with primary antibodies probing AR45 (1:1000; R&D Systems, Cat. No. MAB5876) or G αq (1:250; Santa Cruz, Cat. No. sc-518023) diluted in 1% non-fat milk/TBST solutions.

Techniques: Clinical Proteomics, Expressing